发明名称 |
AMINOMETHYL-BENZOIC ESTER DERIVATIVES AS TRYPTASE INHIBITORS |
摘要 |
The invention relates to the use of compounds of formula (I) wherein R represents hydrogen, alkyl, alkenyl, hydroxy, alkoxy, aminoalkyl, hydroxyalkyl, carboxyalkyl, alkoxyalkyl, amino, halo, cyano, nitro, thiol, alkylthio, haloalkoxy or haloalkyl; Ar represents an optionally substituted carbocyclic or heterocyclic aryl group with the proviso that when Ar represents a naphthyl moiety it is not substituted by amidino or guanidine; and Y represents a hydrogen atom or alkyl group; or a physiologically tolerable salt thereof; for use as tryptase inhibitors. |
申请公布号 |
WO9955661(A1) |
申请公布日期 |
1999.11.04 |
申请号 |
WO1999GB01263 |
申请日期 |
1999.04.23 |
申请人 |
PROTEUS MOLECULAR DESIGN LIMITED;WASZKOWYCZ, BOHDAN;LIVELY, SARAH, ELIZABETH;HARRISON, MARTIN, JAMES |
发明人 |
WASZKOWYCZ, BOHDAN;LIVELY, SARAH, ELIZABETH;HARRISON, MARTIN, JAMES |
分类号 |
A61K31/24;A61K31/277;A61K31/445;A61K31/47;C07C229/38;C07C233/47;C07C235/52;C07C235/74;C07C235/78;C07C255/55;C07C311/29;C07C311/51;C07D207/16;C07D211/62;C07D213/65;C07D215/32;C07D217/02;C07D257/04;C07D295/185;C07D295/192 |
主分类号 |
A61K31/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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