PROCESS FOR THE PREPARATION OF ACECLOFENAC

摘要

Compounds of formula (I), wherein R1, R2 and R3 are independently selected from lower alkyl groups C1-C4 or hydrogen, are particularly useful intermediates in producing Aceclofenac. The compounds are prepared by reacting Diclofenac acid with triethylamine, diisopropylamine or ammonia in a solvent at a temperature of from 20 ~C to 60 ~C. The compounds of formula (I) are reacted with an appropriate .alpha.-haloacetic acid ester to form acetates which are deprotected to form Aceclofenac. Other .alpha.-Arylpropanoic Acid NSAID's may be prepared analogously.