发明名称 |
VACCINES CONTAINING RECOMBINANT PILIN AGAINST NEISSERIA GONORRHOEAE OR NEISSERIA MENINGITIDIS |
摘要 |
The pilE genes of each of Neisseria gonorrhoeae and Neisseria meningitidis a re cloned and their corresponding recombinant pilin proteins are expressed. In addition, a chimeric pilE gene is constructed in which the region of the pil E gene of Neisseria meningitidis class I encoding the amino-terminal region of the pilin protein is replaced by the corresponding region of the pilE gene o f Neisseria gonorrhoeae. The recombinant meningococcal chimeric class I pilin protein is expressed at higher levels than the pilin protein expressed by th e full-length pilE gene of Neisseria meningitidis. Furthermore, a chimeric pil E gene is constructed in which the region of the pilE gene of Neisseria meningitidis class II encoding the carboxy-terminal region of the pilin protein is replaced by the corresponding region of the pilE gene of Neisseri a gonorrhoeae. The recombinant pilin proteins are used in vaccines to protect against disease caused by Neisseria gonorrhoeae or Neisseria meningitidis.</ SDOAB>
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申请公布号 |
CA2325055(A1) |
申请公布日期 |
1999.11.04 |
申请号 |
CA19992325055 |
申请日期 |
1999.04.29 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
OOI, PEGGY;METCALF, THOMAS N., III;ZAGURSKY, ROBERT J. |
分类号 |
C12N15/09;A61K39/00;A61K39/095;A61P31/04;C07K14/22;C07K19/00;C12N1/21;C12N15/31;C12P21/02;(IPC1-7):C12N15/31;C12N15/62 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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