PROCESS FOR THE PREPARATION OF ACECLOFENAC

摘要

Compounds of formula (I), wherein R<1>, R<2> and R<3> are independently selected from lower alkyl groups C1-C4 or hydrogen, are particularly useful intermediates in producing Aceclofenac. The compounds are prepared by reacting Diclofenac acid with triethylamine, diisopropylamine or ammonia in a solvent at a temperature of from 20 DEG C to 60 DEG C. The compounds of formula (I) are reacted with an appropriate alpha -haloacetic acid ester to form acetates which are deprotected to form Aceclofenac. Other alpha -Arylpropanoic Acid NSAID's may be prepared analogously.