DNA SEQUENCES ENCODING SEMAPHORIN-H AND DIAGNOSIS OF METASTATIC CANCER

摘要

The present invention relates to DNA molecules encoding novel members of the Semaphorin family, referred to as Semaphorin-H and Semaphorin-H-v. The invention further relates to polypeptides encoded by the DNA, to antibodies that bind to the polypeptides and to compositions and methods comprising the DNA, polypeptides and antibodies. The present invention provides methods for detecting metastatic cancer and determining the metastatic potential of cells. The invention contemplates the development of cells line with varying metastatic potential for use a models for studying, diagnosing and treating metastatic disease.