发明名称 |
Identification of a human cytomegalovirus gene region involved in down-regulation of MHC class heavy chain expression |
摘要 |
<p>Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down regulation of cell surface expression of MHC class I. The present invention is directed to a mutant with a 9-kb deletion in the S component of the HCMV genome (including open reading frames IRS1-US9 and US11) which failed to down regulate class I heavy chains. By examining the phenotypes of mutants with smaller deletions with this portion of the HCMV genome, a 7-kb region containing at least 9 open reading frames was shown to contain the genes required for reduction in heavy chain expression. Furthermore, it was determined that two subregions (A and B) of the 7-kb region each contained genes which were sufficient to cause heavy chain down regulation. In subregion B, the US11 gene product is involved. It encodes a endoglycosidase H-sensitive glycoprotein which is intracytoplasmic, similar to the adenovirus type 2 E3-19K glycoprotein which inhibits surface expression of class I heavy chains.</p> |
申请公布号 |
AU4452299(A) |
申请公布日期 |
1999.11.04 |
申请号 |
AU19990044522 |
申请日期 |
1999.08.17 |
申请人 |
ANNE E. CAMPBELL;AMERICAN CYANAMID COMPANY |
发明人 |
ANN E. CAMPBELL;THOMAS R. JONES |
分类号 |
C12N15/00;A61K31/70;A61K35/76;A61K38/00;A61K39/245;A61K48/00;A61P31/12;C07K14/045;C12N7/00;C12N7/01;C12N7/04;C12N15/01;C12N15/09;C12N15/34;C12N15/38;C12N15/86;C12N15/861;C12R1/92 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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