| 发明名称 |
G-CSF RECEPTOR AGONIST ANTIBODIES AND SCREENING METHOD THEREFOR |
| 摘要 |
The invention relates to agonist molecules which specifically bind to or interact with human G-CSF receptor and dimerize the receptor or activate phosphorylation of kinases associated with the receptor to stimulate cell proliferation and differentiation. Such agonist molecules include monoclonal antibodies, or fragments, homologues or analogues thereof, or peptides or organic compounds. Two examples of mouse monoclonal agonist antibodies are disclosed: mAb163-93 and mAb174-74-11.
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| 申请公布号 |
CA2326755(A1) |
申请公布日期 |
1999.11.04 |
| 申请号 |
CA19992326755 |
申请日期 |
1999.04.30 |
| 申请人 |
TANOX, INC. |
发明人 |
SUN, BILL N.C.;SUN, CECILY R.Y.;NI, BAOFU |
| 分类号 |
G01N33/50;A61K35/76;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P43/00;C07H21/04;C07K14/535;C07K14/715;C07K16/28;C12N5/10;C12N15/08;C12N15/09;C12P21/08;C12R1/91;G01N33/15;(IPC1-7):C07K16/28;C12N15/13;C12N15/63 |
主分类号 |
G01N33/50 |
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