发明名称 |
Nucleic acid sequences controlling lung cell-specific gene expression |
摘要 |
An oligonucleotide which includes at least one nucleic acid sequence which binds to at least one nuclear protein found in lung cells, such as TTF-1 protein. The oligonucleotide may be contained in a vector. The at least one nuclear protein provides for lung cell-specific expression of the vector upon binding of the at least one nucleic acid sequence to the at least one nuclear protein. Such vector may also include genes encoding therapeutic agents, and may be employed for delivering genes encoding therapeutic agents to lung cells.
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申请公布号 |
US5976873(A) |
申请公布日期 |
1999.11.02 |
申请号 |
US19950442809 |
申请日期 |
1995.05.17 |
申请人 |
CHILDREN'S HOSPITAL MEDICAL CENTER |
发明人 |
BOHINSKI, ROBERT J.;WHITSETT, JEFFREY A. |
分类号 |
G01N33/566;A61K48/00;C07H21/04;C07K14/47;C07K14/785;C12N15/00;C12N15/09;C12N15/85;C12N15/861;C12Q1/68;C12R1/92;(IPC1-7):C12N15/63;C12N15/11;B32B5/16 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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