Determining plasmodium in blood by sphingomyelin synthase activity

摘要

Plasmodium is shown to have an inhibition sensitive sphingomyelin synthase activity necessary for ring and early trophozoite maturation. Inhibitors can therefore be used to identify malarial infection which can differentiate between inhibition sensitive Plasmodium sphingomyelin synthase and mammalian synthase. Inhibitors of interest include 1-phenyl-3-morpholino-2-acylated-aminopropanol-1.