| 摘要 |
PCT No. PCT/JP96/00599 Sec. 371 Date Nov. 4, 1997 Sec. 102(e) Date Nov. 4, 1997 PCT Filed Mar. 7, 1996 PCT Pub. No. WO96/28475 PCT Pub. Date Sep. 19, 1996This invention relates to a PEG-modified HGF (Hepatocyte Growth Factor), namely HGF modified by polyethylene glycol. The PEG-modified HGF of the invention has a prolonged clearance in vivo, effectively exhibits its physiological activity for a long period of time, and has the same physiological activity as HGF, which makes it possible to reduce the dose and relieve the side effects of the same.
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