发明名称 |
N6- substituted nucleotide analagues and their use |
摘要 |
Novel PMP, PME and HPMP and related compounds containing N-6 substituted 2,6-diaminopurine and adenine bases are provided. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame retardants, diagnostic reagents and therapeutics, including antivirals. Of particular note are compounds otherwise not known to possess anti-DNA viral activity that become potent inhibitors of DNA viruses upon substitution of the N-6 site, thereby providing a novel and unexpected and surprising use for such compounds.
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申请公布号 |
US5977061(A) |
申请公布日期 |
1999.11.02 |
申请号 |
US19950426372 |
申请日期 |
1995.04.21 |
申请人 |
INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC;REGA STICHTING, V.Z.W. |
发明人 |
HOLY, ANTONIN;DE CLERCQ, ERIK DESIRE ALICE |
分类号 |
C07D473/16;A61K31/00;A61K31/675;A61P31/00;A61P31/22;C07D473/34;C07F9/6561;C07H19/16;(IPC1-7):A61K31/675;A61K38/02;C07F9/38;C07K2/00 |
主分类号 |
C07D473/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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