3-PYRROLIDINYLTHIO-1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARB-OXYLIC ACID COMPOUND AND PRODUCTION THEREOF

摘要

NEW MATERIAL:A compound expressed by formula I [R<1> is (protected) carboxy; R<2> is (protected) hydroxy (lower) alkyl; R<3> is H or lower alkyl; R<4> is (protected) ureido (lower) alkyl; R<5> is H, lower alkanimidoyl or imide-protecting group; A is lower alkylene] and salts thereof. EXAMPLE:(4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-[(2S,4S)-2 -{(2-ureidoethyl)oxymethyl}pyrrolidin-4-yl]thio-1-azabicyclo[3.2.0]hep t-2-ene-2-carbo xylic acid. USE:An antimicrobial agent, extremely stable to dehydropeptidase and capable of exhibiting high discharge into urine. PREPARATION:For example, a compound expressed by formula II is reacted with a compound expressed by formula III to afford the aimed compound expressed by formula I.