| 摘要 |
A method of forming a polyurethane foam suitable for use as a wound-contacting layer comprises the steps of mixing 1 part weight of an isocyanate-capped prepolymer having 0.5 to 4.8 meq. NCO groups/g with 0.4 to 1.0 parts by weight of water and a non-volatile pharmaceutically-acceptable acid to form a prepolymer mixture; allowing the prepolymer mixture to cure to form a foamed product; followed by drying said product. The mixing step may be carried out in the presence of a monohydric alcohol. The acid is preferably a monocarboxylic acid, e.g. stearic acid, lactic acid, amino acids, a dicarboxylic acid, e.g. sorbic acid, citric acid, malic acid, tartaric acid, or a polycarboxylic acid, e.g. edetic acid, alginic acid, hyaluronic acid. A polyurethane foam is also disclosed, which has a density of at least 0.28 g/cm<SP>3</SP>, less than 1 wt. % of water-soluble alcohols, and at least 1 wt. % of one or more non-volatile pharmaceutically acceptable acids. |
