Substituted Imidazolidin-2,4-dione der4ivatives as immunomodulators

摘要

5,5-Disubstd. 3-heteroaryl-imidazolidine-2,4-dione cpds. of formula (I) are new: R<1> = 1-6C alkyl or 3-6C cycloalkyl; R<2> = 1-6C alkyl, Ph, -(CH2)1-3-Ph or -(CH2)1-4-COOR<5>; or R<1> + R<2> = -(CH2)4-6-, -(CH2)2O(CH2)2- or -CH2-o-C6H4-CH2-; R<3> = H, 1-5C alkyl or -(CH2)1-4-COOR<5>; R<4> = pyridinyl (opt. mono- or disubstd. by Me), pyrazinyl, R<6>-substd. thiazolyl, methyl-substd. isoxazolyl, benzo-2,1,3-thiadiazolyl or 5-(R<7>)-1,3,4-thiadizol-2-yl; R<5> = 1-3C alkyl; R<6> = H, 1-4C alkyl, Ph or benzyl; R<7> = H, 1-4C alkyl or CF3.