| 摘要 |
The invention relates to amides of general formula (I) and their tautomeric and isomeric forms, their possible enantiomeric and diastereomeric forms and possible physiologically compatible salts, where the variables have the following meanings: R1 is C1-C6 alkyl, phenyl, naphthyl, quinolyl, pyridyl, pyrimidyl, pyridazyl, quinazolyl and quinoxalyl, whereby the rings can still be substituted with up to 2 R4 rests; R2 is -(CH2)m-R8, where R8 is phenyl, cyclohexyl or indolyl and m is 1 to 6; X is a bond, -CH2-, -CH2CH2-, -CH=CH-, CC-, -CONH-, -, -SO2NH-, and R1-X together can also be formula (a), R3 is hydrogen and CO-NR6R7; R4 is hydrogen, branched or unbranched C1-C4 alkyl and O-C1-C4-alkyl; R5 is hydrogen, branched or unbranched C1-C4 alkyl and O-C1-C4-alkyl; R6 is hydrogen, branched or unbranched C1-C6 alkyl; R7 is hydrogen, branched or unbranched C1-C6 alkyl; and n is 0, 1 or 2. The amides of formula (I) are inhibitors of enzymes, especially cysteine proteases such as calpains (calcium dependent cysteine proteases) and their isoenzymes and cathepsins, such as B and L.
|
