MICROSPHERES CONTAINING CONDENSED POLYANIONIC BIOACTIVE AGENTS AND METHODS FOR THEIR PRODUCTION
摘要
The present invention relates to novel compositions comprising microspheres and/or nanospheres containing condensed polyanionic bioactive agents, such as DNA. The polyanionic bioactive agent in the microspheres and/or nanospheres is preferably condensed using a polycationic condensing agent, such as poly-L-lysine. The present invention further relates to methods for producing the microspheres and/or nanospheres containing condensed polyanionic bioactive agents.
申请公布号
WO9953903(A1)
申请公布日期
1999.10.28
申请号
WO1999US07383
申请日期
1999.04.23
申请人
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;LEVY, ROBERT, J.;LABHASETWAR, VINOD, D.;COHEN, HAGIT