| 摘要 |
Certain Chlamydia proteins have been found to be infection-specific and to b e associated primarily with the vegetative Reticulate Body form of Chlamydia rather than with the refractile Elementary Body form of Chlamydia. The invention includes a vaccine directed against the Reticulate Body form of Chlamydia comprising one or more infection-specific proteins, or fraction thereof; a method of using such a vaccine; a method of production of such a vaccine; a method for detection of infection-specific antibodies in a biological specimen; a method for detection of infection-specific antigens i n a biological specimen and a method of using therapeutic agents specifically directed against infection-specific peptides, or the genes that code for suc h peptides, to treat chlamydial infection. The invention also includes the Inc B, and IncC proteins of C. psittaci, and nucleotides encoding these proteins, a nd the TroA, TroB and p242 proteins of C. trachomatis, and the nucleotides that encode these polypeptides.
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