HUMAN K<+> ION CHANNEL AND THERAPEUTIC APPLICATIONS THEREOF

摘要

The present invention relates to a novel human K<+> ion channel, to nucleic acid molecules encoding the same and to vectors comprisng said nucleic acid molecules. The invention additionally relates to antibodies specifically directed to the novel K<+> ion channel and to pharmaceutical compositions and diagnostic kits containing at least one of the above-mentioned components. Furthermore, the present invention relates to methods of treating a disease caused by malfunction of the polypeptide of the present invention or by the (over)expression of the nucleic acid molecule of the invention comprising administering an inhibitor of said (over)expression or of ion channel function or an inhibitor abolishing said malfunction to a patient in need thereof. Methods of devising drugs for treating of preventing the above-mentioned disease, methods of inhibiting cell proliferation and methods of prognosing cancer are additional embodiments comprised by the present invention. The invention also envisages specific antisens or gene therapies on the basis of the nucleic acid molecule of the invention for inhibiting undesired cellular proliferation, for example, in connection with cancer or in neurodegenerative diseases.