发明名称 |
MUTANT HAVING URACIL PHOSPHORIBOSYL TRANSFERASE ACTIVITY |
摘要 |
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) activity derived from a native UPRTase by mutation of one or several residues of said UPRTase. The invention also concerns a nucleotide sequence coding for said UPRTase mutant, a vector for expressing the latter, a viral particle and a host cell as well as a composition containing them. The invention further concerns their therapeutic use and a treatment method using them. The invention is particularly useful in the context of therapy by suicide genes in particular for treating proliferative and infectious diseases. |
申请公布号 |
WO9954481(A1) |
申请公布日期 |
1999.10.28 |
申请号 |
WO1999FR00904 |
申请日期 |
1999.04.16 |
申请人 |
TRANSGENE;ERBS, PHILIPPE;JUND, RICHARD |
发明人 |
ERBS, PHILIPPE;JUND, RICHARD |
分类号 |
C12N15/09;A61K38/00;A61K45/00;A61K48/00;A61P31/12;A61P35/00;A61P43/00;C12N5/10;C12N7/00;C12N9/10;C12N15/54;C12N15/55;(IPC1-7):C12N15/54;C12N7/01;C12N15/86;C12N15/62;A61K38/45 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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