N-piperidino-5- (4-chlorophenyl)-1- (2,4-dichlorophenyl)-4- methylpyrazole-3- carboxamide acid addition salts or solvates thereof their preparation and pharmaceutical compositions containing them

摘要

N-Piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyra zole-3-carboxamide of formula: its salts and solvates are powerful antagonists of central cannabinoid receptors. They are prepared by reaction of a functional derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxyli c acid with 1-aminopiperidine and then optional salification.