发明名称 |
Method of determining the formation of platelet thrombi and different uses thereof |
摘要 |
The present invention is an assay for determining glycoprotein IIb/IIIa receptor blockade in whole blood. Agglutinization of small polymeric beads coated with a glycoprotein IIb/IIIa ligand such as fibrinogen results when the beads are contacted with whole blood containing platelets with glycoprotein IIb/IIIa receptors that are not blocked. Failure to agglutinate indicates that blockade of the GPIIb/IIIa receptors has been achieved. In a preferred embodiment, the addition of a thrombin receptor activator results in an assay that is rapid and convenient enough to be performed at bedside and that results in agglutination of the small polymeric beads within a convenient, known period of time if the glycoprotein IIb/IIIa receptors are not blocked.
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申请公布号 |
IL115431(A) |
申请公布日期 |
1999.10.28 |
申请号 |
IL19950115431 |
申请日期 |
1995.09.27 |
申请人 |
MOUNT SINAI SCHOOL OF MEDICINE OF THE CITY UNIVERSITY OF NEW YORK |
发明人 |
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分类号 |
G01N33/50;G01N33/86;(IPC1-7):G01N33/86 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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