| 摘要 |
FIELD: medicine, pharmacology, pharmacy. SUBSTANCE: invention relates to a pharmaceutical preparation based on interleukin-2 as an active substance has a stabilizing agent taken among the group including mannitol, human serum albumin or their mixture, a dissolving agent taken among the group including guanidine hydrochloride, sodium dodecyl sulfate, an antioxidant taken among the group including reduced glutathione, 2-mercaptoethanol or dithiothreitol. The preparation has a pharmaceutically acceptable buffer, stabilizing agent, dissolving agent, antioxidant and buffer taken at the definite ratio of components. The preparation can be prepared in the solid and liquid form and used for treatment of mammals with severe states caused by infection, for example, sepsis of different etiology and oncological illnesses and immunodeficient states also. EFFECT: retention of high biological activity of interleukin-2, decreased adverse effects, improved technology of the preparation producing. 20 cl, 3 tbl, 4 ex |
