A bio-resolution process

摘要

This invention discloses a process for the use of a novel organism belonging to the genus Trichosporon sp. as whole wet or dry cell culture or cell free extract or crude enzyme or pure isolated enzyme. The strain of Trichosporon sp. used in the process is designated as RRLY-15 and has been deposited in Deutsche Sammlung von Mikroorganismen und Zellekulturen GmbH (DSMZ). The invention also discloses the preparation of S(+)-6-methoxy-2-naphthalene acetic acid (naproxen) of formula (2) through enantioselective hydrolyis of a racemic mixture of alkyl esters of (+/-)-6-methoxy- alpha -methyl-2-naphthalene acetic acid of formula (1) where R represents -CH3,-C2H5,-C3H7,-C4H9 and the like and S(+)- Naproxen is a medicinally important non steroidal anti-inflammatory drug.