发明名称 |
Serum immunoregulatory polypeptides and uses therefor |
摘要 |
Previously unisolated serum immunoregulatory polypeptides (SIPs) having a molecular weight of approximately 14,000 to 31,000 are provided. The SIPs may be obtained from hemorrhagic serum of mammals and have been shown to activate suppressor T-cells and suppress lymphocyte proliferation and interleukin production. There is a significant homology between SIPs of different mammalian species. The amino acid sequence of an SIP having a molecular weight of about 16,000 is provided. In addition, immunosuppressive polypeptides are identified which have the formula (SEQ ID NO:2):X-Met-Asp-Ala-His-Pro-Pro-Arg-Leu-Phe-Ala-Cys-Ser-Ywherein X is an amino acid sequence having from 0 to 10 amino acids and Y is an amino acid sequence having from 0 to 110 amino acids.
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申请公布号 |
US5973122(A) |
申请公布日期 |
1999.10.26 |
申请号 |
US19970891056 |
申请日期 |
1997.07.10 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CHANG, YI-HAN;ABRAHAM, EDWARD |
分类号 |
A61K38/00;C07K14/47;C07K16/18;G01N33/68;(IPC1-7):C07K7/00;C07K14/745 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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