发明名称 |
Plasmodium falciparum MHC class I-restricted CTL epitopes derived from pre-erythrocytic stage antigens |
摘要 |
PCT No. PCT/GB93/00711 Sec. 371 Date Dec. 5, 1994 Sec. 102(e) Date Dec. 5, 1994 PCT Filed Apr. 5, 1992 PCT Pub. No. WO93/20103 PCT Pub. Date Oct. 14, 1993A method of identifying peptides of an antigen of interest which are capable of recognition by or induction of cytotoxic T lymphocytes, comprises the steps of: ascertaining a "motif" of peptides which bind to a chosen HLA class I allele; providing peptides having this motif which are present in the known sequence of the antigen of interest; screening the peptides using an HLA assembly assay; and screening the resulting peptides for recognition by or induction of cytotoxic T lymphocytes. The above peptides have been identified by this method, and the peptides and vaccines containing them are also claimed.
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申请公布号 |
US5972351(A) |
申请公布日期 |
1999.10.26 |
申请号 |
US19940318856 |
申请日期 |
1994.12.05 |
申请人 |
ISIS INNOVATION LIMITED |
发明人 |
HILL, ADRIAN VIVIAN SINTON;GOTCH, FRANCES MARGARET;ELVIN, JOHN;MCMICHAEL, ANDREW JAMES;WHITTLE, HILTON CARTER |
分类号 |
A61K39/00;A61P33/06;C07K14/155;C07K14/445;(IPC1-7):A61K39/015;A61K38/04 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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