发明名称 |
Helicobacter pylori nickel binding protein |
摘要 |
The application discloses a nickel binding protein and its encoding DNA isolated from Helicobacter pylori. This organism is the primary cause of chronic gastritis and ensuing peptic ulcers, and has been implicated in stomach cancer. The nickel binding protein is useful to inhibit assembly of active ureases, the enzymes responsible for the pathogenic features of the bacterium. Potential uses include as a vaccine, a diagnostic, a drug target, and a therapy in itself.
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申请公布号 |
US5972348(A) |
申请公布日期 |
1999.10.26 |
申请号 |
US19980115032 |
申请日期 |
1998.07.14 |
申请人 |
NEW ENGLAND MEDICAL CENTER HOSPITALS INC. |
发明人 |
PLAUT, ANDREW G.;GILBERT-ROTHSTEIN, JOANNE V.;WRIGHT, ANDREW |
分类号 |
G01N33/566;A61K38/00;A61K39/00;A61P31/04;C07K14/195;C07K14/205;C07K16/12;C12N15/09;C12Q1/04;C12Q1/68;G01N33/15;G01N33/569;(IPC1-7):A61K39/02 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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