| 摘要 |
PROBLEM TO BE SOLVED: To inexpensively obtain an opium derivative useful as an intermediate for synthesizing morphinoid compounds simply in high yield and in high purity by oxidizing a specific compound under an oxidative condition. SOLUTION: This compound shown by formula II is obtained by oxidizing a compound shown by formula I (R<1> and R<2> are each a lower alkyl or the like) or a salt thereof (preferably, a phosphate salt) (e.g. codeine), under an acidic condition, preferably at pH 0.8-4.5, more preferably at pH 0.8-1.2, preferably using, as an oxidizing agent, manganese dioxide such asγ-manganese dioxide, preferably at an ambient, temperature for 1.5-4 h, preferably in a solvent, such as acetone.
|
