| 摘要 |
The present invention provides a compound of the formula wherein R is selected from the group consisting of CH3, CH2CH3, (CH2)2CH3, (CH2)3CH3, (CH2)4CH3, (CH2)5CH3, (CH2)6CH3, (CH2)2O(CH2)3CH3, CH2HC=CH(CH2)3CH3, CH2C 3BOND C(CH2)3CH3, CH2C 3BOND C(CH2)2CH3, CH2C 3BOND CCH2CH3, CH2C 3BOND CCH3 and CH2C 3BOND CH; and R' is selected from the group consisting of CH3, CF3, CH2Cl and CH2Br or a pharmaceutically acceptable salt or hydrate thereof. Also provided is a method of inhibiting the synthesis of prostaglandin endoperoxide syntase-2 (PGHS-2) in a mammal.
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