发明名称 |
G-protein fusion receptors and chimeric gabab receptors |
摘要 |
The present invention features G-protein fusion receptors and chimeric GABAB receptors (GABABRs), nucleic acid encoding such receptors, and the use of such receptors and nucleic acid. G-protein fusion receptors comprise at least one domain from a CaR, a mGluR, and/or a GABAB receptor fused directly or through a linker to a guanine nucleotide-binding protein (G-protein). Chimeric GABABRs comprise at least one of a GABABR extracellular domain, a GABABR transmembrane domain, or a GABABR intracellular domain and one or more domains from a mGluR subtype 8 (mGluR8) and/or a CaR. |
申请公布号 |
AU3380199(A) |
申请公布日期 |
1999.10.25 |
申请号 |
AU19990033801 |
申请日期 |
1999.04.02 |
申请人 |
NPS PHARMACEUTICALS, INC. |
发明人 |
THOMAS M STORMANN;LANCE G. HAMMERLAND;LAURA L. STORJOHANN;JAMES G. BUSBY;JAMES E. GARRETT;RACHEL T. SIMIN |
分类号 |
C12N15/00;A61K38/00;C07K14/47;C07K14/705;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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