发明名称 Dichelants
摘要 This invention relates to dichelants, in particular compounds having two macrocyclic chelant groups linked by a bridge containing an ester or amide bond, especially compounds of formula Vb (wherein each X which may be the same or different is NZ, O or S, at least two Xs being NZ; each Z is a group R1 or a group CR12Y, at least one Z, and preferably 2 or 3 Zs, on each macrocyclic ring being a group CR12Y; each Y is a group CO2H, PO3H, SO3H, CONR12, CON(OR1)R1, CNS or CONR1NR12, preferably COOH; m is 0 or 1 or 2, preferably 1; each n is 2 or 3, preferably 2; q is 1 or 2, preferably 1; each R1 which may be the same or different is a hydrogen atom or an alkyl group optionally substituted by one or more hydroxy and/or alkoxy groups; and D is a bridging group having a molecular weight of less than 1000, preferably less than 500, joining two macrocyclic rings via at least one amide or ester bond) and salts and metal chelates thereof.
申请公布号 US5972307(A) 申请公布日期 1999.10.26
申请号 US19970898376 申请日期 1997.07.22
申请人 NYCOMED SALUTAR, INC. 发明人 CARVALHO, JOAN;WATSON, ALAN D.;FELLMANN, JERE D.;KOO, MICHAEL
分类号 A61K49/00;A61K49/06;C07C237/06;C07C237/10;C07C237/12;C07D241/06;C07D257/02;C07D295/185;C07D403/14;C07F9/6524;C07F19/00;(IPC1-7):A61K51/04;A61B5/055;C07F5/00;C07D225/00 主分类号 A61K49/00
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