PROCESS FOR PRODUCING HALOGENATED beta -LACTAM COMPOUND

摘要

A process for producing a halogenated beta -lactam compound represented by general formula (4), characterized by reacting a beta -lactam-derived amino compound represented by general formula (1) with nitrous acid or a nitrite in the presence of halogen molecules under acid conditions while keeping the reactants in an aqueous slurry state to obtain the target compound. In formula (1) n is an integer of 0 to 2; and A represents formula (2) or (3), wherein R<1> and R<2> are the same or different and each is hydrogen, halogeno, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, a nucleophilic group, or CH2R<3>, where R<3> represents halogeno or a nucleophilic group. In formula (4) A is the same as the above; X<1> represents hydrogen or halogeno; and X<2> represents halogeno.