SECRETION OF GLYCOSYLATED PROTEINS USING A TISSUE PLASMINOGEN ACTIVATOR PRO-SEQUENCE

摘要

DNA constructs, host cells and production methods are disclosed for the expression and recovery of polypeptides, especially those altered to have one or more glycosylation sites added or deleted. The DNA constructs, host cells and methods provided herein employ a DNA segment corresponding to a mammalian tissue plaminogen activator signal and/or pro-peptide.