发明名称 |
PROCESS FOR ALKYLATING HINDERED SULFONAMIDES USEFUL IN THE PRODUCTION OF MATRIX METALLOPROTEINASE INHIBITORS |
摘要 |
The present invention relates to a process for the preparation of compounds of formula (b), in which a compound of formula (V) is reacted with a compound of formula (VI). The resulting compound of formula (IV) is reduced to a compound of formula (III) which is hydrolysed to a compound of formula (b). Alternatively, a compound of formula (IV) is hydrolysed to a compound of formula (a) which is reduced to a compound of formula (b). Compounds of formula (IV) are novel. In the formulae the variables are as defined in the claims. Compounds of formula (b) are useful as intermediates in the preparation of matrix metalloproteinase inhibitors.
|
申请公布号 |
CA2327498(A1) |
申请公布日期 |
1999.10.21 |
申请号 |
CA19992327498 |
申请日期 |
1999.04.09 |
申请人 |
PFIZER PRODUCTS INC. |
发明人 |
HAMMEN, PHILIP DIETRICH;ANDRESEN, BRIAN MICHAEL;HAWKINS, JOEL MICHAEL |
分类号 |
A61K31/223;A61K31/351;A61P1/00;A61P1/02;A61P1/04;A61P3/10;A61P9/00;A61P9/04;A61P9/10;A61P11/00;A61P17/02;A61P19/02;A61P19/10;A61P25/00;A61P25/04;A61P25/06;A61P25/14;A61P25/16;A61P25/24;A61P25/28;A61P27/02;A61P29/00;A61P31/04;A61P31/18;A61P35/00;A61P35/04;A61P37/04;A61P37/06;A61P37/08;A61P43/00;B01J23/44;C07B61/00;C07C303/36;C07C303/40;C07C311/29;C07C311/37;C07D309/14;C07D311/00;C07D493/06;C07D493/08;(IPC1-7):C07C303/40 |
主分类号 |
A61K31/223 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|