PYRUVATE CARBOXYLASE OVEREXPRESSION FOR ENHANCED PRODUCTION OF OXALOACETATE-DERIVED BIOCHEMICALS IN MICROBIAL CELLS

摘要

Metabolic engineering is used to increase the carbon flow toward oxaloacetate to enhance production of bulk biochemicals, such as lysine and succinate, in bacterial fermentations. Carbon flow is redirected by genetically engineering the cells to overexpress the enzyme pyruvate carboxylase.