| 摘要 |
<p>Vitamin D derivatives represented by general formula (I), intermediate compounds in the synthesis thereof, and medicinal compositions containing these vitamin D derivatives as the active ingredient wherein A represents linear or branched C2-10 alkylene; and R represents SO3R1 (wherein R1 represents hydrogen or linear or branched C1-3 alkyl) or COOR2 (wherein R2 represents hydrogen or linear or branched C1-3 alkyl). These compounds have affinities for vitamin D receptors and vitamin D-binding proteins and are useful as drugs such as remedies for diseases based on calcium metabolic errors. Moreover, these compounds are considered as the metabolites of vitamin D derivatives substituted at the 2 beta -position, in particular, 2 beta -(3-hydroxypropoxy)-1 alpha ,25-dihydroxyvitamin D3 and are useful as a specimen in identifying the same.</p> |
