NOVEL THERAPEUTIC AGENTS INTERFERING IN NEUTROPHIL MIGRATION

摘要

The present invention provides methods and means to influence neutrophil migration which occurs in a number of serious illnesses, such as acute trauma and inflammatory diseases. In bacterial meningitis for instance a high influx of neutrophils in the brain leads to an unfavourable prognosis. Typically IL-8 is involved in chemoattracts of neutrophils. According to the present invention glucoronoxylmannan or a functional equivalent thereof is used to interfere with neutrophil migration. This constitutes a first medical use of this group of substances.