发明名称 |
CHROMANONE AND THIOCHROMANONE DERIVATIVES |
摘要 |
The invention concerns compounds of formula (I), wherein R1 and R2 independently are hydrogen, acyl, alkoxycarbonyl or alkyl; either the sulfamoyloxy side chain is bound to the 6 position; R3 is alkyl; alkenyl; alkinyl; a cycloalkyl moiety optionally substituted by alkyl, alkoxy or halogen; arylalkyl; arylalkenyl; arylalkinyl; acyl; cycloalkylalkyl; 3-oxo-2-oxacamphanyl; 6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl; a heteroaryl moiety optionally substituted by alkyl, alkoxy or halogen; or is heteroarylalkyl; and R4 is hydrogen; alkyl; hydroxy; or alkoxy; or the sulfamoyloxy side chain is bound to the 7 position; R3 has the significance indicated above for R4; and R4 has the significance indicated above for R3; X is O or S; and the symbol <u>---</u> is a single or a double bond; in free form or salt form. They can be prepared by sulfamoylation of corresponding hydroxylated compounds, by reduction and/or by N-substitution. They are indicated for use as pharmaceuticals, particularly in the prophylactic or curative treatment of illnesses responsive to steroid sulfatase inhibition.
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申请公布号 |
WO9952890(A1) |
申请公布日期 |
1999.10.21 |
申请号 |
WO1999EP02349 |
申请日期 |
1999.04.07 |
申请人 |
NOVARTIS AG;NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH;BILLICH, ANDREAS;NUSSBAUMER, PETER;SCHREINER, ERWIN;SCHUSTER, INGEBORG |
发明人 |
BILLICH, ANDREAS;NUSSBAUMER, PETER;SCHREINER, ERWIN;SCHUSTER, INGEBORG |
分类号 |
A61K31/352;A61K31/382;A61P5/28;A61P5/32;A61P13/08;A61P15/00;A61P17/08;A61P17/14;A61P35/00;A61P43/00;C07D311/22;C07D335/06;(IPC1-7):C07D311/22;A61K31/35 |
主分类号 |
A61K31/352 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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