New benzamide derivatives useful as cysteine protease inhibitors for treating neurodegenerative diseases, neuronal damage, stroke, cranial trauma, Alzheimer's disease, etc.

摘要

Carboxybenzamide derivatives (I) are new.- DETAILED DESCRIPTION - Carboxybenzamide derivatives of formula (I) and their tautomers, isomers and salts are new: - R1 = 1-6C alkyl, phenyl, naphthyl, quinolyl, pyridyl, pyrimidinyl, pyridazinyl, quinazolinyl or quinoxalinyl, all optionally substituted by 1-2 R4 groups; - R2 = (CH2)mR8; - R8 = phenyl, cyclohexyl or indolyl; - m = 1-6; - X = a bond; CH2, CH2CH2, CH=CH, ethynylene, CONH or SO2NH; or - R1-X = a group of formula (i) or (ii): - R3 = H or CONR6R7; - R4, R5 = H, 1-4C alkyl or 1-4C alkoxy; - R6, R7 = H or 1-6C alkyl; - n = 0-2.- ACTIVITY - None given.- MECHANISM OF ACTION - Cysteine protease inhibitor