AMINOPIPERIDINE DERIVATIVES AS INTEGRIN .ALPHA.V.BETA.3 ANTAGONISTS

摘要

Compounds having integrin .alpha.v.beta.3 antagonism, cell adhesion inhibito ry effect, GP IIb/IIIa antagonism and/or human platelet agglutination inhibitor y effect; and remedies for cardiovascular diseases, diseases in association wi th neovascularization, cerebrovascular diseases, etc. and platelet agglutinatio n inhibitors. The above compounds involve derivatives represented by general formula (I), pharmaceutically acceptable salts thereof and solvates of the same, wherein A represents a 5- to 7-membered heterocycle containing two nitrogen atoms; D represents NH2, CH2, etc.; X and Z represent each CH or N; R7 and R8 represent each alkyl, halogeno, etc.; Q represents C=O, CH2, etc.; R9 represents H, alkyl, aralkyl, etc.; R10 represents H, alkynyl, etc.; R11 represents H, substituted amino, etc.; R12 represents H or alkyl; m is from 0 to 5; n is from 0 to 4; p and q are each from 1 to 3; and r is 0 or 1.