NOVEL COMPOUNDS

摘要

Compounds of formula (I) or pharmaceutically acceptable salt thereof where the broken circle is a monocyclic or bicyclic aryl or heteroaryl ring; n and p are independently integers from 1 to 4 and (n+p) is from 2 to 5; R is hydrogen or up to three substituents selected from halogen, NO2, CN, N3, CF3O-, CF3S-, CF3CO-, trifluoromethyldiazirinyl, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO-, C1-6alkylCO-, C3-6cycloalkylO-, C3-6cycloalkylCO-, C3-6cycloalkyl-C1-4alkylO-, C3-6cycloalkyl-C1-4alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS-, C1-6alkylSO2-, (C1-4alkyl)2NSO2-,(C1-4alkyl) and HSO2-, (C1-4alkyl)2, and CO-, (C1-4alkyl)NHCO, CONH2, CF3SO2, C1-6alkenyl, C1-6alkynyl or C1-6hydroxyalkyl; or -NR<a>R<b> where R<a> is hydrogen or C1-4alkyl, and R<b> is hydrogen, C1-4alkyl, formyl, -CO2C1-4alkyl or -COC1-4alkyl; or two R groups together form a carbocyclic ring that is saturated or unsaturated and unsubstituted or substituted by -OH or =O; and R<4> is hydrogen or C1-6alkyl, R<5> is hydrogen or C1-6alkyl, are useful in the treatment and prophylaxis of certains CNS disorders.