OPTIMIZED NUCLEOTIDE SEQUENCE ENCODING ORGANOPHOSPHOROUS HYDROLASE AND METHODS OF USE FOR SAME

摘要

A nucleotide sequence is disclosed which is optimized for plant expression and which encodes organophosphorous hydrolase. Expression constructs, transformation vectors as well as transformed cells are also disclosed which achieve expression levels superior to those demonstrated by expression in bacteria such as E. coli for high throughput production of the enzyme. Transgenic plants may themselves be used or the protein may be harvested from said plants for in situ or other environmental detoxification of organophosphorous neurotoxin contaminated areas.