发明名称 Medicinal compositions of peptides with EACA or tranexamic acid for enhanced mucosal absorption
摘要 PCT No. PCT/JP95/01085 Sec. 371 Date Dec. 2, 1996 Sec. 102(e) Date Dec. 2, 1996 PCT Filed Jun. 2, 1995 PCT Pub. No. WO95/33474 PCT Pub. Date Dec. 14, 1995Disclosed is a medicinal composition, which comprises a peptide as an effective ingredient and as bases, epsilon aminocaproic acid or tranexamic acid and an ethylene oxide-propylene oxide block copolymer represented by the following formula (I):HO(C2H4O)a-(C3H6O)b-(C2H4O)cH(I)wherein a, b and c stand for integers of 1 or greater, respectively. According to this medicinal composition, the peptide can be absorbed at a high rate through the mucosa and further, its pharmacological effects are prolonged over for a long time.
申请公布号 US5968899(A) 申请公布日期 1999.10.19
申请号 US19960737930 申请日期 1996.12.02
申请人 TSUMURA & CO. 发明人 SEKINE, TAKASHI;ISHIKAWA, KAZUYUKI;KIMURA, TAKAYOSHI;NAKAI, YOSHINOBU
分类号 A61K38/23;A61K47/10;A61K47/18;(IPC1-7):A61K38/17;A61K38/09;A61K38/10;A61K38/16 主分类号 A61K38/23
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