| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new antisense oligonucleotide which specifically hybridizes to a chromosomal DNA and/or RNA coding for CXCR4 protein to inhibit the expression of the protein, and useful, for example, as a medicine for treatment and prophylaxis of the HIV infection. SOLUTION: This is a new antisense oligonucleotide which specifically hybridizes to a chromosomal DNA and/or RNA coding for CXCR4 protein to inhibit the expression of CXCR4 protein, contains at least one of sequences shown by formulas I-III, and is useful as an anti-HIV medicine which is highly effective, for example, as medicines for prophylaxis and treatment of human immunodeficiency viruses(HIV). This antisense oligonucleotide is obtained by synthesizing a base sequence complementary to a base sequence from +429 to +758 (gene transcription initiation point of mRNA coding for CXCR4 protein being +1) on a DNA synthesizer by the phosphoramidite method, followed by purifying by reversed phase HPLC and so on. |
