Pyrazolones derivatives

摘要

PCT No. PCT/JP96/02944 Sec. 371 Date Apr. 13, 1998 Sec. 102(e) Date Apr. 13, 1998 PCT Filed Oct. 11, 1996 PCT Pub. No. WO97/13757 PCT Pub. Date Apr. 17, 1997A pyrazolone derivative represented by general formula (I) or a salt thereof: [wherein one of X1 and X2 is (wherein A is a cyano group, a cyano C1-4 alkyl group, an amino group, an amino C1-4 alkyl group, an amidino group or a guanidino group, R1 and R2 are independently hydrogen atoms, halogen atoms, C1-6 alkyl groups or the like) or the like], the other of X1 and X2 is a C1-6 alkyl group, a C3-6 alkenyl group, an aryl C1-4 alkyl group or an aryl group, one of Y1 and Y2 is (wherein Q is an oxygen atom or a sulfur atom, Z1 is an oxygen atom, a -NR7- group or a -CHR7- group, Z2 is a cyclic C3-7 alkylene group, a C1-3 alkylene group, a -CH2CO- group or -CH2CH2CO- group, Z3 is an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group or the like, Z4 is a C1-3 alkylene group, and Z5 is a carboxyl group or the like, and the other of Y1 and Y2 is a D-E- group [wherein E is a bond, a C1-4 alkylene group or a phenylene group, and D is a hydrogen atom, a C1-6 alkyl group or the like which has an inhibitory action on platelet aggregation and is useful as a preventive or therapeutic agent for various thrombotic diseases.