发明名称 |
Antisense oligonucleotide modulation of human HER-2 expression |
摘要 |
Compounds, compositions and methods are provided for inhibiting the expression of human HER-2 (also known as c-neu, ErbB-2 and HER-2/neu). The compositions comprise antisense oligonucleoptides targeted to nucleic acids encoding HER-2. Methods of using these oligonucleotides for inhibition of HER-2 expression and for treatment of diseases such as cancers associated with overexpression of HER-2 are provided. Methods of inhibiting other growth factor receptors using antisense oligonucleotides targeted to nucleic acids encoding HER-2 are also provided.
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申请公布号 |
US5968748(A) |
申请公布日期 |
1999.10.19 |
申请号 |
US19980048804 |
申请日期 |
1998.03.26 |
申请人 |
ISIS PHARMACEUTICALS, INC.;THE PENN STATE RESEARCH FOUNDATION |
发明人 |
BENNETT, C. FRANK;LIPTON, ALLAN;WITTERS, LOIS M. |
分类号 |
A61K38/00;C12N15/113;(IPC1-7):C12Q1/68;C12N15/85;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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