发明名称 |
HBV polymerase processes for preparation and uses for screening antiviral agents thereof |
摘要 |
The present invention relates to hepatitis B virus (hereinafter it refers to HBV) polymerase containing a histidine tag, RNase H enzyme derived from HBV polymerase and processes for preparation thereof. More particularly, the present invention relates to recombinant HBV polymerase, its RNase H domain with enzyme activity, expression vectors producing the enzymes in E. coli and processes for preparing the HBV polymerase and the RNase H enzyme which can be easily purified due to their histidine tags. And the present invention relates to uses of the HBV polymerase and the RNase H enzyme for screening antiviral agents.
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申请公布号 |
US5968781(A) |
申请公布日期 |
1999.10.19 |
申请号 |
US19970911774 |
申请日期 |
1997.08.15 |
申请人 |
DONG WHA PHARM. IND. CO., LTD. |
发明人 |
YOON, SUNG-JUNE;KIM, JONG-WOO;HUH, YONG;RHO, HYUNE-MO;JUNG, GU-HUNG |
分类号 |
G01N33/15;C12N1/21;C12N9/12;C12N9/22;C12N15/09;C12N15/54;C12P21/04;C12R1/19;G01N30/88;(IPC1-7):C12N9/12;C12N15/62 |
主分类号 |
G01N33/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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