| 摘要 |
PCT No. PCT/GB96/02766 Sec. 371 Date May 14, 1998 Sec. 102(e) Date May 14, 1998 PCT Filed Nov. 13, 1996 PCT Pub. No. WO97/18206 PCT Pub. Date May 22, 1997The present invention relates to compounds of formula (I) wherein X is a 5- or 6-membered C-linked heteroaromatic ring containing 1 to 4 nitrogen atoms and optionally containing in the ring one oxygen or sulphur atom; Y is a group of the formula -(CH2)nNR6R7 or a methylene- or ethylene-linked imidazolyl group; Z is hydrogen or C1-4alkyl optionally substituted by a hydroxy group; R1, R2, R3, R4, R5, R9aand R9b are a variety of substituents; R6 is hydrogen, C1-6akyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, phenyl, or C2-4akyl substituted by C1-4alkoxy or hydroxy, R7 is hydrogen, C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, phenyl, or C2-4alkyl substituted by one or two substituents selected from C1-4alkoxy, hydroxy or a 4-, 5- or 6-membered heteroaliphatic ring containing one or two heteroatoms selected from N, O and S; or R6 and R7, together with the nitrogen atom to which they are attached, form a saturated or partially saturated heterocyclic ring or a non-aromatic azabicyclic ring system; and n is zero, 1 or 2; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherapeutic neuralgia.
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