THF- gamma 2 analogs and pharmaceutical compositions comprising them

摘要

An immunomodulatory peptide is disclosed which is a thymic humoral factor gamma 2 (THF- gamma 2) analog of at least eight amino acids or a functional derivative or a salt thereof. The peptide has the amino acid sequence: Leu-Glu-Asp-Gly-Pro-Lys-Phe-Leu (SEQ ID No:1) but differing therefrom by (i) addition of one to three amino acids at the N- and/or C-terminus; (ii) substitution of one to four amino acids by a protein natural or non-natural amino acid; (iii) cyclization through a free carboxyl group and a free amino group or through disulfide bonds of cysteines residues; or (iv) linkage of two to four sequences of modified sequences of (I) corresponding to anyone of (i), (ii), or (iii) above, through a peptidic or non-peptidic linkage.