| 摘要 |
An antibody or antibody fragment with a binding affinity for the CD3 antigen, having a human constant region, and human or rat variable framework region, a heavy chain with CDRs having the amino acid sequences: (a) Ser-Phe-Pro-Met-Ala (SEQ ID NO:1), (b) Thr-Ile-Ser-The-Ser-Gly-Gly-Arg-Thr-Tyr-Tyr-Arg-Asp-Ser-Val-Lys-Gly (SEQ ID NO:2), (c) Phe-Arg-Gln-Tyr-Ser-Gly-Gly-Phe-Asp-Tyr (SEQ ID NO:3), and light chain with CDRs having the amino acid sequences: (d) Thr-Leu-Ser-Ser-Gly-Asn-Ile-Glu-Asn-Tyr-Val-His (SEQ ID NO:4), (e) Asp-Asp-Asp-Lys-Arg-Pro-Asp (SEQ ID NO:5), (f) His-Ser-Tyr-Val-Ser-Ser-Phe-Asn-Val (SEQ ID NO:6), in which the heavy chain CDRs are arranged in the order (a), (b), (c) in the leader->constant region direction and the light chain CDRs are arranged in the order (d), (e), (f) in the leader->constant region direction.
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