| 摘要 |
<p>Compounds, represented by the following formula (I), having a beta -(substituted or unsubstituted imidazoÄ5,1-bÜthiazolyl)vinyl group at the 3-position of the cephem ring and a salt and an ester thereof are disclosed. The compounds have antibacterial activity against a very wide spectrum of bacteria and potent antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and resistant bacteria. <CHEM> wherein X represents CH or N, R<1> represents a hydrogen atom or an amino protective group, R<2> represents a hydrogen atom, a C1-6 alkyl group, a C3-7 cycloalkyl group, or a hydroxy protective group, R<3> is absent or represents a hydrogen atom, a salt forming cation, or a carboxyl protective group, R<4>, R<5>, and R<6>, which may be the same or different, each independently represent a hydrogen atom or a C1-6 alkyl group, R<7+> is absent or a cation of a C1-6 alkyl, and n is an integer of 0 to 1.</p> |
